PDT describes the photochemical reaction that occurs after applying a light sensitive agent (ALA) which is absorbed by abnormal skin cells and sebaceous glands, then activated by light in the target cells.

As the light photons are absorbed by the photosensitive agent a singlet oxygen is generated which damages the cell directly.

What can be treated using ALA-PDT?

Various superficial skin problems especially those from sun damage eg photorejuvation to improve texture and colour of skin.

Non-melanocytic skin tumours or premalignant lesions such as actinic keratoses, SCC and BCCs.

Also sebaceous problems eg acne vulgaris, rosacea

In general, ALA-PDT can be viewed as a way of accelerating the results of laser or IPL photorejuvation procedures, cutting down the number of treatments needed to achieve optimal results eg with ALA-PDT can reduce skin rejuvenation from 6 + sessions to 2-3 sessions.

How is PDT done?

First the light sensitive cream (ALA) is applied to skin and allowed to absorb in for an hour or more. Then the photo chemical reaction is activated by exposing the treated skin to the suitable wavelength of light from laser or other light device.

To get best results PDT may need to be repeated 1-4 week interval.

Is it painful?

When the laser or light activates the ALA-PDT some burning, itchiness or discomfort is often felt but it will vary depending on what skin problem one is treating.

When can I go back to work?

Some immediate redness, swelling and later crusting will usually develop. It may be up to 7 days for that to settle. Also, we advise staying indoors for 24 hours after ALA-PDT treatment as the skin will be still very sensitive to sun light.

What are the side effects?

Apart from the initial expected redness, swelling and crusting it is possible but rare for scarring to occur.

Hyperpigmentation or hypopigmentation if occurs is temporary.